Postdoc in Computational Biology and Modelling of Cell Therapy Dynamics – funded by AIRC

Overview APPLICATION CLOSING DATE : October 2nd, 2025 Application instructions Please apply online by submitting a single document that includes: a CV, a motivation letter in English (max 1 page long), and the names and contacts of at least 2 referees. The Organization Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centres: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally. About the lab Dr Alice Giustacchini’s research group combines experimental and computational biology in a collaborative environment at Human Technopole (HT), utilizing state-of-the-art technologies and interdisciplinary expertise. The group collaborates closely with clinical teams at UCL and Ospedale Pediatrico Bambino Gesù, connecting basic science with clinical practice to ensure translational impact. By addressing key challenges in hematologic malignancies, the group aims to drive advancements in precision medicine and develop innovative approaches to improve therapeutic outcomes. The Giustacchini Lab, part of the Population and Medical Genomics Centre at HT, is seeking a postdoc in computational biology to investigate the cellular and molecular dynamics of CAR T-cell therapy in blood cancers. This project will focus on modelling the in vivo interactions between CAR T cells, tumour cells, and normal haematopoiesis, using state-of-the-art single-cell multiomics data and computational approaches. The aim is to uncover mechanisms driving therapeutic resistance, tumour reshaping, and hematopoietic impact under CAR T-cell pressure, with implications for improving immunotherapy strategies for hematologic malignancies. The project will be run in collaboration with Prof Marco Masseroli at Politecnico di Milano. The successful candidate will collaborate closely with a dynamic team of researchers and computational biologists within the Population and Medical Genomics Centre and the Computational Biology Centre and will engage in joint projects with the groups of Lorenzo Calviello, Andrea Sottoriva and Francesco Iorio. J-18808-Ljbffr

Location: Vercelli, Piemonte, IT

Posted Date: 9/17/2025